Spark Biomedical

Clinical Trials

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Our clinical trials focus on demonstrating the efficacy of transcutaneous auricular neurostimulation (tAN®). Through these studies, we're exploring how wearable neurostimulation can provide reliable, on-demand support for people dealing with challenging symptoms.

This approach opens new doors for patients who need effective, drug-free management options, particularly those who may not respond well to standard treatments or who seek alternatives to traditional pharmaceuticals.

Clinical Trials

Link Publications
Concurrent taVNS-fMRI Revealed Similar Brain Activation Patterns Elicited by Stimulation of the Mastoid and the Cymba Conchae

Status:

Concurrent taVNS-fMRI Revealed Similar Brain Activation Patterns Elicited by Stimulation of the Mastoid and the Cymba Conchae

Overview

Neuromodulation: Technology at the Neural Interface, 2026

MUSC - Jeff Borckardt and Xiaolong Peng

Download Whitepaper
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Number of Subjects
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ClinicalTrials.gov ID
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Lead Organization
MUSC - Jeff Borckardt and Xiaolong Peng
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Funding Source
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Partners
No items found.
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Journal Publication
No current publications
Link Publications
Transcutaneous Auricular Neurostimulation Modulates Pain Perception in Survivors of Stroke with Chronic Upper-Extremity Pain: A Randomized, Sham-Controlled Pilot Study

Status:

Transcutaneous Auricular Neurostimulation Modulates Pain Perception in Survivors of Stroke with Chronic Upper-Extremity Pain: A Randomized, Sham-Controlled Pilot Study

Overview

Neuromodulation: Technology at the Neural Interface, 2026

MUSC - Jeff Borckardt and Xiaolong Peng

Download Whitepaper
people icon gray
Number of Subjects
government trial ID icon teal
ClinicalTrials.gov ID
teal icon of city building representing a business or organization
Lead Organization
MUSC - Jeff Borckardt and Xiaolong Peng
teal money icon representing the source of funding
Funding Source
blue icon of partners and handshake
Partners
No items found.
journal publication icon teal
Journal Publication
No current publications
Link Publications
Accelerated Transcutaneous Auricular Vagus Nerve Stimulation for Inpatient Depression and Anxiety: The iWAVE Open Label Pilot Trial

Status:

Accelerated Transcutaneous Auricular Vagus Nerve Stimulation for Inpatient Depression and Anxiety: The iWAVE Open Label Pilot Trial

Overview

Neuromodulation: Technology at the Neural Interface, 2025

MUSC - Bashar Badran

Download Whitepaper
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Number of Subjects
government trial ID icon teal
ClinicalTrials.gov ID
teal icon of city building representing a business or organization
Lead Organization
MUSC - Bashar Badran
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Funding Source
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Partners
No items found.
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Journal Publication
No current publications
Spark Publications
The protocol for a randomized, sham-controlled trial of transcutaneous auricular neurostimulation for chronic pain and opioid withdrawal symptoms during a 4-day opioid taper for adults in the United States

Status:

The protocol for a randomized, sham-controlled trial of transcutaneous auricular neurostimulation for chronic pain and opioid withdrawal symptoms during a 4-day opioid taper for adults in the United States

Overview

Trials, 2025

Protocol only paper for tANdem

Download Whitepaper
people icon gray
Number of Subjects
government trial ID icon teal
ClinicalTrials.gov ID
teal icon of city building representing a business or organization
Lead Organization
teal money icon representing the source of funding
Funding Source
blue icon of partners and handshake
Partners
No items found.
journal publication icon teal
Journal Publication
No current publications
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