Clinical Trials

The LUNA study is a prospective, randomized, double-blind, sham-controlled, decentralized clinical trial in participants with heavy menstrual bleeding of no known structural cause. The study includes two age-based cohorts: adolescents aged 14-21 and adults aged 22-45. Participants in both cohorts will be randomized to receive transcutaneous auricular neurostimulation (tAN), which targets the auricular branch of the vagus nerve (ABVN) and the auriculotemporal nerve (ATN), or sham stimulation. Participants will be enrolled into the study over the course of five consecutive menstrual cycles. All study activities will occur remotely and in addition to participants' typical treatment for HMB (as allowed by the eligibility criteria).

This open-label, single arm, single-site clinical trial is investigating the safety, feasibility, and preliminary efficacy of transcutaneous auricular neurostimulation to improve outcomes in children with abdominal pain related to disorders of gut-brain interaction. Participants use device for one hour daily over four weeks with a four week follow-up period.

This pilot trial will evaluate the feasibility and acceptability of its procedures and the appropriateness of the tAN intervention for firefighter with Alcohol Use Disorder and Post-Traumatic Stress

This study is designed to test optimal parameters of transcutaneous auricular stimlation (tAN) for the reduction of COWS scores in individuals in precipitated withdrawal. The investigators will evaluate the effects of various tAN stimulation frequencies on NLX-precipitated withdrawal (4mg, intranasal)